The World Health Organization, U.S. Centers for Disease Control and Prevention, and the American Cancer Society each recommend nicotine replacement therapy (NRT) as first line therapy for tobacco cessation. In addition, they note vaping is not a suitable substitution for cigarette smoke as it also has carcinogenic effects. [1,2,3] Current smoking cessation clinical guidelines and recommendations do not mention cannabidiol (CBD) as a therapeutic option. However, the National Institute on Drug Abuse does stress that marijuana products, those containing tetrahydrocannabinol (THC), should not be utilized. 
A 2021 review of available evidence in the use of cannabidiol in substance use found 3 studies (see tables 1 and 2) of CBD in tobacco smoking cessation or current tobacco smokers. However, these studies did not meet the review’s inclusion criteria as they either lacked direct comparison with control group, and/or utilized surrogate markers as the only measured outcomes.  The third study identified in the review used a single dose of CBD and did not find any change in verbal or spatial working memory, or impulsivity during tobacco abstinence.