Table 1: Humira® and  FDA-approved Biosimilars

Agent Name

Adalimumab

Adalimumab-adbm

Adalimumab-afzb

Adalimumab-ryvk

Adalimumab-atto

Adalimumab-adaz

Adalimumab-bwwd

Adalimumab-fkjp

Adalimumab-aqvh

Adalimumab-aacf

Adalimumab-aaty

Other Name

D2E7

BI 695501

PF-06410293

AVT02

ABP 501

GP2017

SB5

FKB327

CHS-1420

MSB11022

CT-P17

Brand Name

Humira® (AbbVie)

Cyltezo® (Boehringer Ingelheim)

Abrilada® (Pfizer)

Simlandi (Alvotech)

Amjevita™ (Amgen)

Hyrimoz® (Sandoz)

Hadlima™ (Samsung Bioepis)

Hulio® (Biocon Biologics)

Yusimry™ (Coherus BioSciences)

Idacio® (Fresenius Kabi)

Yuflyma® (Celltrion)

Interchangeable with Reference Agent?

Reference

Yes

Yes

Yes

No

No

No

No

No

No

No

FDA Approval Date

12/31/2002

08/25/2017

11/15/2019

02/23/2024

09/23/2016

10/30/2018

07/23/2019

07/06/2020

12/17/2021

12/13/2022

05/23/2023

FDA Approved Indications

Rheumatoid Arthritis (Adults)

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Juvenile Idiopathic Arthritis (≥2 yo)

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Psoriatic Arthritis (Adults)

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Ankylosing Spondylitis (Adults)

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Crohn’s Disease (≥6 yo)

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Ulcerative Colitis (Adults)

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Ulcerative Colitis (≥5 yo)

Yes

No

No

No

No

No

No

No

No

No

No

Plaque Psoriasis (Adults)

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Yes

Hidradenitis Suppurativa (Adults)

Yes

Yes

Yes

Yes

Yes

No

Yes

Yes

Yes

No

Yes

Hidradenitis Suppurativa (≥12 yo

Yes

No

No

No

No

No

No

No

No

No

No

Uveitis (Adults)

Yes

Yes

Yes

Yes

Yes

No

Yes

Yes

Yes

No

Yes

Uveitis (≥2 yo)

Yes

No

No

No

No

No

No

No

No

No

No

Note: There are variations in indications, dosage form strength, latex content, and excipients among the agents. For more details, please refer to the Prescribing Information.